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Final Project Summary Published

The Final Project Summary for the FP7 BioElectricSurface Project has been published and is available for download on the project website.

Download this file (BioElectricSurface Final Project Summary.pdf)BioElectricSurface Final Project Summary.pdf[Final Project Summary Document]439 Kb

Last Updated (Friday, 25 April 2014 12:53)


Monograph on the creation and characterisation of nanodomains and biological interactions (Deliverable 2.5)


*** UPDATE: RSC selected the Project Book as its Book of the Month for August (2012)***




Biological Interactions with Surface Charge in Biomaterials
Book Cover
Tofail Syed (Editor)
ISBN: 978-1-84973-185-0
[ Book Link ]


When a biomaterial is placed inside the body, a biological response is triggered almost instantaneously. With devices that need to remain in the body for long periods, such interactions can cause encrustation, plaque formation and aseptic loosening on the surface. These problems contribute to the patient's trauma and increase the risk of death. Electrical properties, such as local electrostatic charge distribution, play a significant role in defining biological interactions, although this is often masked by other factors.

This book describes the fundamental principles of this phenomenon before providing a more detailed scientific background. It covers the development of the relevant technologies and their applications in therapeutic devices such as MRSA-resistant fabrics, cardiovascular and urological stents, orthopaedic implants, and grafts. Academic and graduate students interested in producing a selective biological response at the surface of a given biomaterial will find the detailed coverage of interactions at the nanometre scale useful. Practitioners will also benefit from guidance on how to pre-screen many inappropriate designs of biomedical devices long before any expensive, animal or potentially risky clinical trials.

Last Updated (Sunday, 16 June 2013 23:29)

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A facile aqueous sol–gel method for high surface area nanocrystalline CeO2

P. Periyat, F. Laffir, S. A. M. Tofail and E. Magner

Thermally stable high surface area nanocrystalline CeO2 was synthesized via an aqueous sol–gel method using cerium hydroxide and urea as precursors. The CeO2 sol is yellow colored and absorbs light over the range 200–500 nm. Nanocrystalline CeO2 particles derived from the sol are spherical in shape and range from 9 to 13 nm in diameter. The CeO2 powder has a high surface area of up to 85 m2 g−1 and a band gap of 3.1 eV. The method of preparation is facile, utilises low cost reagents and can be performed on a large scale.

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Directly created electrostatic micro-domains on hydroxyapatite: probing with a Kelvin Force probe and a protein


Plecenik, Tomas; Robin, Sylvain; Gregor, Maros; Truchly, Martin; Lang, Sidney; Gandhi, Abbasi; Zahoran, Miroslav; Laffir, Fathima; Soulimane, Tewfik; Vargova, Melinda; Plesch, Gustav; Kus, Peter; Plecenik, Andrej; Tofail, S. A. M.

Micro-domains of modified surface potential (SP) were created on hydroxyapatite films by direct patterning by mid-energy focused electron beam, typically available as a microprobe of Scanning Electron Microscopes. The SP distribution of these patterns has been studied on sub-micrometer scale by the Kelvin Probe Force Microscopy method as well as lysozyme adsorption. Since the lysozyme is positively charged at physiological pH, it allows us to track positively and negatively charged areas of the SP patterns. Distribution of the adsorbed proteins over the domains was in good agreement with the observed SP patterns.


Last Updated (Tuesday, 13 December 2011 13:06)

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Charge Specific Protein Placement at Submicrometer and Nanometer Scale by Direct Modification of Surface Potential by Electron Beam

Sylvain Robin, Abbasi A. Gandhi, Maros Gregor, Fathima R. Laffir, Tomas Plecenik, Andrej Plecenik, Tewfik Soulimane, and Syed A. M. Tofail

The understanding and the precise control of protein adsorption is extremely important for the development and optimization of biomaterials. The challenge resides in controlling the different surface properties, such as surface chemistry, roughness, wettability, or surface charge, independently, as modification of one property generally affects the other. We demonstrate the creation of electrically modified patterns on hydroxyapatite by using scanning electron beam to tailor the spatial regulation of protein adsorption via electrostatic interactions without affecting other surface properties of the material. We show that domains, presenting modulated surface potential, can be created to precisely promote or reduce protein adsorption.

Last Updated (Tuesday, 13 December 2011 13:08)

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