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BioElectricSurface FP7 Project

Monograph on the creation and characterisation of nanodomains and biological interactions (Deliverable 2.5)

 

Biological Interactions with Surface Charge in Biomaterials
Book Cover
Tofail Syed (Editor)
ISBN: 978-1-84973-185-0
[ Book Link ]

Synopsis

When a biomaterial is placed inside the body, a biological response is triggered almost instantaneously. With devices that need to remain in the body for long periods, such interactions can cause encrustation, plaque formation and aseptic loosening on the surface. These problems contribute to the patient's trauma and increase the risk of death. Electrical properties, such as local electrostatic charge distribution, play a significant role in defining biological interactions, although this is often masked by other factors.

This book describes the fundamental principles of this phenomenon before providing a more detailed scientific background. It covers the development of the relevant technologies and their applications in therapeutic devices such as MRSA-resistant fabrics, cardiovascular and urological stents, orthopaedic implants, and grafts. Academic and graduate students interested in producing a selective biological response at the surface of a given biomaterial will find the detailed coverage of interactions at the nanometre scale useful. Practitioners will also benefit from guidance on how to pre-screen many inappropriate designs of biomedical devices long before any expensive, animal or potentially risky clinical trials.

Last Updated (Tuesday, 13 December 2011 14:02)

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Journal of Colloid And Interface Science Publication

 

Article title: In situ photoexcitation of silver doped titania nanopowders for activity against bacteria and yeasts

Journal title: Journal of Colloid And Interface Science


Abstract Photocatalytic and in situ microbial activity of the amorphous and annealed states of Ag-doped and un-doped titania, were examined. Studies on their structure, morphology, composition and the photo-absorption characteristics of these materials, were performed.

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European Research Team Develop textiles to kill MRSA Superbug in Hospitals

PRESS RELEASE 18-3-2011

Partners of a European Commission funded research project have developed textiles that will kill the MRSA (Methicillin Resistant Staphylococcus Aureus) superbug. The European research team, BioElectricSurface (www.bioelectricsurface.eu), has used nanomaterials that activate agents to kill MRSA on textiles used in hospital drapes*, bed linens and upholstery. Nanomaterials, which are a thousand times smaller than a human hair, are known to possess extra-ordinary physical and chemical properties.

 

Coordinator and UL Team

 

Last Updated (Thursday, 14 April 2011 19:58)

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Project Introduction

Research area: NMP-2007-1.1-1 Nano-scale mechanisms of bio/non-bio interactions.

The project will develop methods to manipulate surface charge on biomaterials surfaces by electrical modification.

This surface charge is critical in mediating bio/non bio interactions in vivo.

The project will develop novel nanoscale techniques to obtain a quantitative insight into biological interactions on the biomedical device surfaces.

The research will provide valuable understanding of biological interactions at the nanometer scale and will apply this understanding to develop plaque-resistant cardiovascular stents, stone free urological stents, rapid-healing orthopaedic implants and MRSA-resistant self sterilising hospital gowns.

Last Updated (Wednesday, 28 July 2010 00:38)

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